As a splicing factor, RBM20 regulates the splicing of heart-related genes involved in ventricular diastolic function and sarcomere assembly, including TTN, Ryr2, and CAMKII (Guo et al, 2012; Kayvanpour et al, 2017; Ma et al, 2016), thereby contributing to various cardiovascular diseases such as arrhythmia, dilated cardiomyopathy (DCM), myocardial insufficiency, and extensive myocardial fibrosis (Lennermann et al, 2020). This evidence concerns the gene TTN and familial dilated cardiomyopathy.