RYR2 and familial dilated cardiomyopathy: As a splicing factor, RBM20 regulates the splicing of heart-related genes involved in ventricular diastolic function and sarcomere assembly, including TTN, Ryr2, and CAMKII (Guo et al, 2012; Kayvanpour et al, 2017; Ma et al, 2016), thereby contributing to various cardiovascular diseases such as arrhythmia, dilated cardiomyopathy (DCM), myocardial insufficiency, and extensive myocardial fibrosis (Lennermann et al, 2020).