Moreover, CTTN-Δe11 silencing in cardiomyocytes of RBMS1-overexpressing mice significantly mitigated the pathological manifestations of cardiac hypertrophy induced by TAC surgery (Fig. 7D,E), reduced cardiac fibrosis (Fig. 7D,F; Appendix Fig. S8I), improved cardiac architecture and inflammatory infiltration (Appendix Fig. S8J,K), and decreased cardiomyocyte cross-sectional area (Fig. 7D,G). Here, CTTN is linked to cardiac hypertrophy.