RBMS1 and hydrops fetalis: To uncover the underlying pathway of RBMS1 in pathological cardiac hypertrophy, we utilized WGCNA approach to construct RBMS1 co-expression module based on RNA sequencing dataset (GSE135055) (Appendix Fig. S9A,B), and identified 279 genes (MEyellow) co-expressed with RBMS1 were the strongest association with HF (Appendix Fig. S9C).