In conclusion, these findings provide the first insight that RBMS1 promotes cardiac hypertrophy by generating CTTN-Δe11 isoform and activating PI3K/AKT signaling pathway to disorganize the sarcomere and cytoskeleton of cardiomyocyte. The Synopsis was generated on the https://www.home-for-researchers.com/#/. This evidence concerns the gene CTTN and hypertrophy.