A summary volcano plot depicted a substantial number of differentially expressed genes in response to RBMS1 overexpression (Appendix Fig. S3B), and these genes were markedly enriched in pathways related to cytoskeleton, ECM, and hypertrophic cardiomyopathy (Appendix Fig. S3C,D). The gene discussed is RBMS1; the disease is hypertrophic cardiomyopathy.