Combining volcanic map and GO analysis to identify the differential splicing genes enriched in HCM and DCM, we identified five potential target genes subjected to RBMS1 regulation (Fig. 5B), among which CTTN exhibited a distinct exon 11 skipping pattern (CTTN-Δe11), and which exhibited the most pronounced upregulation in RBMS1-overexpressed NMCMs (Fig. 5C; Appendix Fig. S4A–D). Here, CTTN is linked to familial dilated cardiomyopathy.