RIP-qPCR assay subsequently validated that circ-EGFR was significantly enriched in the AGO2 group instead of IgG control in CRC, indicating that circ-EGFR likely binds to RNA-induced silencing complex (RISC) and sponge corresponding miRNAs (Fig. 4A). The gene discussed is EGFR; the disease is colorectal carcinoma.