Given that one of the primary gene regulatory functions of circRNAs is to impact tumor pathogenesis by serving as competing endogenous RNAs (ceRNAs) through their interaction with miRNAs (Han et al, 2017; Kleaveland et al, 2018; Yang et al, 2018), we explored the ability of circ-EGFR to act as a molecular sponge for miRNAs in CRC. The gene discussed is EGFR; the disease is neoplasm.