During the development of intrahepatic cholangiocarcinoma, activated HSCs transition into myofibroblasts (myCAFs) and inflammatory CAFs (iCAFs), which promote the progression of intrahepatic cholangiocarcinoma through the Has2/HA pathway and HGF/MET pathway, respectively [43, 44]. The gene discussed is HGF; the disease is intrahepatic cholangiocarcinoma.