TP53 and neoplasm: Furthermore, treatment of dormant tumor cells with extracted neutrophil lipid components resulted in increased proliferation rates (Fig. S10A), increased proliferative capacity (Fig. S10B), and decreased expression of DNA damage markers along with senescence-associated p53/p21 pathway proteins (Fig. S10C-D), confirming the functional role of neutrophil lipids in reactivation of dormancy in tumor cells.