PMS2 and Lynch syndrome: Notably, a study in patients with CRC associated with Lynch syndrome found that 1.6% (15/969) of cases tested positive for the BRAF V600E variant, and 1.7% (8/482) were positive for MLH1, 0.7% (2/269) for MSH2, 9.3% (5/54) for PMS2, and 0% (0/27) for MSH6 [296].