APC and adenoma: A Japanese study in which 123 patients with ≥ 10 adenomatous polyps in the colon/rectum were investigated by next-generation sequencing identified pathogenic APC variants in 93% of patients with dense adenomatous polyposis, 72% of those with sparse adenomatous polyposis, and 17% of those with < 100 adenomas, suggesting a correlation between the density of colorectal adenomas and the detection rate of pathogenic APC variants [35].