MSH6 and colorectal carcinoma: Furthermore, the cumulative incidence of CRC by the age of 40 years was 0.09%–2.5% for MSH6 and 0.07–0.7% for PMS2 in females and 1.2%–9.9% for MSH6 and 0.5%–2.1% for PMS2 in males [434].