According to studies of germline multi-gene panel testing (*MGPT) for CRC patients, FAP accounts for 0.5% and Lynch syndrome for 3% of cases, with GPVs in ATM, CHEK2, MUTYH, and TP53 also observed, resulting in approximately 5% of CRCs being HCRC [7, 8]. The gene discussed is TP53; the disease is colorectal carcinoma.