The CT50 of serotype-a strain (Hia) was moderately elongated from 0.5 min in WT mice to 1.7 min in Crp−/− mice (Fig. 4A; Appendix Fig. S3A), which was accompanied by substantial reduction in hepatic trapping of Hia at 5 min post infection (Fig. 4A, right panel). This evidence concerns the gene CRP and infection.