CRP and bacterial infectious disease: Many studies have attempted to define an anti-infection function of CRP in mice by passive administration or transgenic expression of human CRP, because it is believed that the low levels of endogenous CRP in mouse plasma (<2 μg/ml) are insufficient to manifest the function of the copious human CRP during bacterial infections (Bray et al, 2016; Ji et al, 2023; Ngwa and Agrawal, 2019).