We compared our findings with those reported by Zaborsky et al. Notably, in that study, all TCL1 mice, harboring a dominant IGHV11 CLL clone (ID 212, ID 221, ID 347, ID D22; n = 4) exhibited mutations (stop gain, non-frameshift deletions and non-synonymous) in genes associated with the AKT/mTOR pathway, including PTEN, PIK3R1, PIK3CA, ITGA7, KRAS and EGF18. The gene discussed is PTEN; the disease is B-cell chronic lymphocytic leukemia.