As the mTOR signaling pathway is influenced by both mutational alterations and transcriptional deregulation in mice harboring a dominant IGHV11 CLL clone, these findings might suggest that the mTOR pathway may play a more prominent role in IGHV11 CLL clones compared to IGHV1 CLL clones. The gene discussed is MTOR; the disease is B-cell chronic lymphocytic leukemia.