MADD and neoplasm: The Tumor volume in the MADD knockout group (32.5 ± 7.5 mm3) was significantly smaller than that in the vehicle control (434.0 ± 401.3 mm3), plasmid control (180.8 ± 56.53 mm3), and drug control (151.8 ± 44.43 mm3) groups (p < 0.005).