Furthermore, by screening for the common genes among the differentially expressed genes in the transcriptome, the differentially expressed genes of T cells in single-cell sequencing, and the key module genes in WGCNA, CXCL13, GNLY, IFI6, IFI27, IFI44, IFI44L, MX1, and TIGIT are ultimately extracted as the key disease genes of DLE, and these genes are closely associated with the mechanism regulating T cell function. This evidence concerns the gene GNLY and discoid lupus erythematosus.