We explore various chimeras of different SOD1 binding proteins and E3 ligases using a panel of seven single-chain variable fragments (scFvs) derived from monoclonal antibodies that bind to aggregated SOD1 in SOD1-ALS patient tissue8, soluble aggregated SOD130, and toxic seeding species of mutant and WT misfolded SOD18,31,32. Here, SOD1 is linked to amyotrophic lateral sclerosis.