In hepatocellular carcinoma (HCC), SIRT1 deacetylates p62 at K295, preventing its degradation, activating mTORC1, and promoting hepatocarcinogenesis [57], while PCAF enhances autophagic flux by inhibiting Akt/mTOR, thereby inducing cancer cell death [58]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.