To further validate this finding, we treated tumor-bearing mice with ectopic expression of KAT6B::ADK and ADK with tamoxifen in vivo, and tumors overexpressing KAT6B::ADK showed a minimal response to tamoxifen treatment, in contrast to the significant tumor inhibition in the control group (Fig. 4g and Supplementary Fig. S6p). The gene discussed is KAT6B; the disease is neoplasm.