Importantly, ablation has also been shown to induce immunogenic cell death and trigger the release of tumor antigens, tumor necrosis factor-α and heat shock proteins, which act as “danger signals” to activate systemic anti-tumor immune responses.16,17 Furthermore, several reports including ours have documented a durable abscopal effect in a NSCLC patient treated with ablation after developing resistance to immunotherapy,18,19 highlighting the potential synergy between ablation and immunotherapy in patients with ORD.20 Here, TNF is linked to neoplasm.