VHL and nonpapillary renal cell carcinoma: To investigate the metabolism of ccRCC with an intact blood supply, we performed metabolomic, transcriptomic, and proteomic analyses on intraoperative multiregional samples taken from 5 patients with VHL-mutant ccRCC undergoing 13C 6-glucose infusions at the time of radical nephrectomy surgery (Fig. 1A and Table 1).