This resulted in known high-impact variants, such as rs144651842-A in IL4R, rs2305479-T in GSDMB, and rs113135335-G in BCL2L11 for asthma, and rs34210653-A in ALOX15 for CRSwNP, and novel variant associations such as the atopic dermatitis-associated31 rs183884396-A in TESPA1 for asthma. The gene discussed is GSDMB; the disease is atopic eczema.