This tendency for a more pronounced effect on CRSwNP was also observed in previously asthma-specific loci, such as 16p13.3 near CLEC16A and 16p12.1 near IL4R. Such findings align with prior observations9 regarding loci like 9p24.1 near IL33, 5q22.1 near TSLP, and 10p14 near GATA3, which were among the first identified as related to CRSwNP17,18,23. The gene discussed is IL33; the disease is asthma.