NEK6 and chronic rhinosinusitis without nasal polyps: For CRSsNP, we identified five GWS loci (Supplementary Fig. 2, Supplementary Data 3), including one novel association at 9q33.3, near NEK6. The locus, previously linked to allergic rhinitis and vitiligo, associated with CRSsNP (OR = 1.069 [95 % CI 1.044–1.094], p = 2.28e-8).