IL33 and asthma: We also provide evidence of a trend of shared loci having a higher absolute risk increase for CRSwNP, including many loci traditionally considered asthma-specific, such as 5q22.1 near TSLP, or 9p24.1 near IL33. This is in line with clinical observations, where some biologics targeting asthma pathways have shown impact on CRSwNP as well7,21, and even improved impact in patients with both diseases20.