2) Depending on the disease, the subcellular localisation of the pathological inclusions is different: in SCA1, SCA3/MJD, SCA7, and SCA17, they are mainly nuclear [30, 39–42], while in SCA6 and SCA2, they are cytoplasmic [43, 44], although there are some reports of nuclear inclusions in SCA2 patients [38, 45, 46]. Here, CASP3 is linked to Machado-Joseph disease.