It has been shown in RA that Notch ligands JAG1 and JAG2, as well as DLL1 and DLL4, are upregulated on different cell types, including fibroblast-like synoviocytes, endothelial cells, and macrophages, which can shape the commitment of attracted monocytes through Notch receptors [52]. This evidence concerns the gene JAG1 and rheumatoid arthritis.