SPOP and colorectal carcinoma: To verify the biological function of SPOP in CRC, we first constructed SPOP-knockdown cell lines (Fig. 2A) and found that SPOP knockdown increased the proliferative ability of CRC cells via a CCK8 assay (Fig. 2B), while a cycle assay suggested that SPOP could change the cycle distribution of CRC cells (Fig. 2C).