ADRA2A and Hypertension: While we observed repression of a handful genes involved in cardiomyocyte differentiation through BMP axis (BMPR1B) [49], survival (BIRC3) [50] sarcomere organization (RAC2) [51], and hypertension (ADRA2) [52, 53]; in YAP1-KO CMs, we did not observe binding to previously described non-CM targets such as CTGF, CYR61, and AXL or to CM specific hypertrophy associated targets containing TEAD consensus sequence such as MYH7 or NFAT.