The group mCRPC has lower TXNIP and CDKN1D (p27kip1) expression than localized PCa, along with higher levels of SLC2A1 (GLUT1) and the AR-response gene FKBP5. In the cohort of histological human samples, no differences were observed in GLUT1, although our data is obtained from a small cohort due to the difficulty of accessing post-ADT human tissue for histological analysis. Here, FKBP5 is linked to posterior cortical atrophy.