Thus, to confirm the mechanistic role of TXNIP in the process of ADT resistance, we generated a model of PCa-Txnip knock-out mouse by crossing PCa TRAMP C57/Bl6 mice with a systemic Txnip knock-out (Txnip−/−) C57/Bl6 model [19]. The gene discussed is TXNIP; the disease is posterior cortical atrophy.