INS and Insulin resistance: Postload glucose intolerance predominantly reflects peripheral insulin resistance, whereby postprandial glucose levels remain elevated because of impaired glucose uptake by muscles.23,24 Reduced insulin sensitivity has indeed been associated with lower muscle mass.25,26 Although we did not directly measure muscle mass, women with GD-P participated in significantly less moderate-to-vigorous physical activity and had smaller waist circumferences than those with other subtypes.