On the other hand, fasting hyperglycemia generally reflects hepatic insulin resistance, whereby the liver overproduces glucose because of insufficient suppression.27 Chronic inflammation stemming from visceral obesity is believed to be a top culprit for dysfunctional insulin signaling in the liver,24 which aligns with the higher adiposity observed in the GD-F and GD-M subtypes. This evidence concerns the gene INS and Insulin resistance.