GLP-1 RAs/dual GIP/GLP-1 RAs + ketogenic diet: both liraglutide and tirzepatide have been associated with the ketogenic diet with good results: the association with tirzepatide leading to more significant fat mass loss and muscle mass preservation [191], that with low dose liraglutide (up to 1.8 mg) leading to more significant weight loss and marked insulin resistance improvement [192]. The gene discussed is GCG; the disease is Insulin resistance.