There were four upregulated genes; three are associated with progression or severity of heart failure (Efnb3, Alox12 and 5430431a17Rik), whereas Kcna6 encodes for a pore-forming subunit of the Kv1 voltage-gated potassium transporter involved in membrane repolarisation during the cardiac action potential and prolongation of the QT interval (STZ-T1D+RS vs STZ-T1D+RH; Fig. 5b, Table 4). The gene discussed is EFNB3; the disease is heart failure.