Several outstanding studies have demonstrated that interleukin-10 (IL-10), the C-X-C motif chemokine ligand 13 (CXCL13), and circulating tumor DNA (ctDNA) in CSF are reliable markers for adjuvant diagnosis of CNSL, but lack universal applicability due to methodological complexity or inconsistent diagnostic thresholds [4, 5]. The gene discussed is IL10; the disease is neoplasm.