CD8 T cell proliferation in response to cDC1 that have taken up AC under non-inflammatory conditions is associated with tolerance (Ferguson et al., 2002; Liu et al., 2002; Steinman et al., 2000) while AC uptake under inflammatory conditions, such as in some tumor therapy settings or with bacterially infected AC, may contribute to immunity (Desch et al., 2011; Penteado et al., 2017; Torchinsky et al., 2009; Xie et al., 2022). Here, CD8A is linked to neoplasm.