The top 25 genes whose reduced expression was most strongly associated with lower %SO included JAK1 (Janus kinase 1), STAT6 (signal transducer and activator of transcription 6), and GNS (glucosamine N-acetyl-6-sulfatase), which may be related to downregulation of airway epithelial mucus hypersecretion, a key target in CF disease attenuation by ETI therapy. This evidence concerns the gene JAK1 and cystic fibrosis.