Orai1 immunofluorescence staining in paraffin-embedded lung sections from control and patients with PVOD demonstrate that Orai1 was localized in hPASMCs and pulmonary vein SMC (hPVSMCs), with an increased Orai1 staining intensity in the remodeled PA and pulmonary veins from patients with PVOD (Figure 8B). The gene discussed is ORAI1; the disease is pulmonary venoocclusive disease.