MAPT and Alzheimer disease: UK4 (Figure g), receptor-interacting protein kinases3 (RIPK3) relevant to necrotic pathways in humans (Figure h), the synaptic translation regulator Orb2 involved in Drosophila memory (Figure i), and uperin 3.5(Figure j) and aurein3.3 (Figure k) involvedin amphibian antimicrobial responses. Moreover, fibrils formed from the same protein can be polymorphic.The tau protein, for example, forms fibrils with core structures thatcan have pathology-specific folds, including in AD, Pick’sdisease, chronic traumatic encephalopathy, corticobasal degeneration,progressive supranuclear palsy, and others.