The model demonstrates robust performance across specimen types (biopsies and surgical resections, 0.804 and 0.912, respectively), histologic subtypes (adenocarcinoma and non-adenocarcinoma, 0.880 and 0.801, respectively), and EGFR mutation subtypes (AUROC, 0.854–0.931). The gene discussed is EGFR; the disease is adenocarcinoma.