These patients remained at high risk of admission to MICU after multivariable adjustment for SOFA score, PaO2/FiO2 ratio, CKD, heart failure, chronic liver disease, WBC, Hgb, ALB, D-dimer, AST, and C-reactive protein (CRP) (SMAT4: OR 4.731, 95% CI 1.853–12.075; SMIT4: OR 6.449, 95% CI 2.422–17.170) (Figure 4A). The gene discussed is ALB; the disease is heart failure.