TLR3 and neoplasm: While our findings are specific to cutaneous HPV disease, studies in other epithelial tumors have reported associations between tumor‐cell TLR3 and clinical outcomes—favorable prognosis in triple‐negative breast cancer and apoptosis upon experimental activation in non‐small‐cell lung cancer—highlighting clinical interest in epithelial TLR patterns while underscoring differences in disease context [23, 24].