While the prolyl hydroxylation of HIFα is suppressed under hypoxia, leading to HIFα accumulation and heterodimerization with HIF1β (ARNT), which then binds the hypoxia response elements (HREs) to promote transcription of genes essential for cancer cell proliferation, angiogenesis, and etc (Lee et al., 2021; Losman et al., 2020; Semenza, 2012; Yang & Kaelin, 2001). This evidence concerns the gene ARNT and cancer.