Although e8a2 BCR::ABL1 transcripts have been reported previously (5, 6), we describe a rare case of CML in which the e8a2 transcript contains an in-frame 154 bp insertion derived from SPECC1L exon 4 between BCR exon 8 and ABL1 exon 2. Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.