Researchers conducted whole exome sequencing on FNH component and two HCC components, and the results showed that 80 non-synonymous mutations(such as ATG5, ANGPT1, HNRNPA2B1, CBL) were found to coexist among the three, with HCC specific mutations including MYCN and MAP2K4; In addition, the telomerase reverse transcriptase gene(TERT) promoter regions of all three carry the hotspot mutation −c.124 C > T (30). Here, MAP2K4 is linked to hepatocellular carcinoma.