ODC1 and neoplasm: The factors contributing to NaCl’s role in tumorigenesis can be delineated as follows: 1) Decreases gastric mucus viscosity, compromising the mucosal barrier (99, 103); 2) Elevates ornithine decarboxylase (ODC) activity and replicative DNA synthesis (RDS), indicators of tumor promotion (101); 3) Augments lipid peroxidation associated with gastric epithelial proliferation (103, 104).