Based on clinicopathological and molecular data from 440 patients, the model integrated eight independent predictors—including HBV-DNA load, tumor size, ES grade, tumor capsule integrity, MVI classification, presence of satellite nodules, Ki-67 index, and CK19 expression—and demonstrated excellent discriminative ability (C-index = 0.773 in the training cohort and 0.764 in the validation cohort) and calibration performance. This evidence concerns the gene MKI67 and neoplasm.