It is reported that Snail or Slug induces tamoxifen resistance in breast cancer by activating EGFR/ERK pathway independent of EMT, and inhibitors of EGFR/ERK pathway can restore the sensitivity of cancer cells with high expression of Snail/Slug to tamoxifen, without reversing the EMT phenotype of these cells (241). This evidence concerns the gene SNAI2 and breast carcinoma.