In this study, we verified that LCR is the best indicator for assessing the inflammation burden in GC by comparing the prediction accuracy of 16 systemic inflammatory indicators including CRP, LCR, PNI, NLR, GLR, ALI, SII, CAR, CONUT, mGPS, GNRI, mGNRI, AGR, NRI, PLR, and LCS using clinical data derived from a large cohort of patients with GC. The gene discussed is CRP; the disease is gastric cancer.