DMAPT, a water-soluble analog of the natural sesquiterpene lactone parthenolide, has been shown to inhibit NF-κB signaling and eradicate tumor cells in various cancers, including acute myelogenous leukemia, NSCLC, prostate cancer, and PDAC (120–123). This evidence concerns the gene NFKB1 and acute myeloid leukemia.