NFKB1 and alcohol abuse: In addition to conventional NF-κB inhibitors, several promising repurposed drugs targeting the NF-κB pathway have been identified, including nafamostat mesylate, a synthetic serine protease inhibitor; disulfiram-copper complex, used to treat alcohol use disorder; niclosamide, an anti-helminthic agent; and celecoxib, a non-steroidal anti-inflammatory drug.