NFKB1 and Familial prostate cancer: For instance, the combination of DHMEQ, a compound derived from a natural product, with 4 Gy of irradiation produced a synergistic antitumor effect in LNCaP and PC-3 prostate cancer cells by inhibiting radiation-induced NF-κB and upregulating the expression of cell cycle-related proteins, such as p53 and p21 in LNCaP, and 14-3-3σ in PC-3 cells (98).