For instance, promethazine, a first-generation antihistamine with sedative and antiemetic properties, has been shown to inhibit the PI3K/AKT/mTOR signaling in chronic myeloid leukemia by downregulating phosphorylated PI3K (p-PI3K) (86). This evidence concerns the gene PIK3CA and chronic myelogenous leukemia, BCR-ABL1 positive.