Isoflurane inhibits growth, migration, and invasion of hepatic carcinoma cells.It promotes apoptosis.Regulates aggressiveness of cancer cells via the PI3K/AKT-mediated NF-κB signaling pathway by suppresses PI3K and AKT expression.Downregulates NF-κB activity, reducing inflammation and tumor progression. Here, PIK3CA is linked to hepatocellular carcinoma.