A diagnostic model incorporating four-lncRNAs panel (RNA component of mitochondrial RNA processing endoribonuclease [RMRP], Taurine up-regulated gene 1 [TUG1], Nuclear paraspeckle assembly transcript 1 [NEAT1] and Metastasis associated lung adenocarcinoma transcript 1 [MALAT1]) achieved AUCs of 0.89, outperforming traditional lung cancer-related tumor marker combinations (CEA, CA125, and CYFRA21-1) for the diagnosis of adenocarcinoma (64). This evidence concerns the gene CEACAM5 and neoplasm.