HAVCR2 and subcutaneous panniculitis-like T-cell lymphoma: While the pathophysiology of SPTCL remains uncertain, biallelic germline coding variants in the hepatitis A virus-cellular receptor 2 (HAVCR2) gene, resulting in decreased expression of the immune checkpoint T-cell immunoglobulin mucin (TIM3), are increasingly implicated in driving the immune dysregulation underlying this disease and are associated with an increased risk of HPS.4