For this reason, our novel mouse model was based on an App knock-in mouse (APP-TKI; Saito et al., 2014; Sasaguri et al., 2017) that does not overexpress APP (Figure 1), yet develops robust amyloid deposits at an early age (Figure 3) and exhibits behavioral and pathological phenotypes that are the hallmarks of AD (Saito et al., 2014; Masuda et al., 2016; Sasaguri et al., 2017; Tan et al., 2023). The gene discussed is APP; the disease is Alzheimer disease.