IL6 and autoimmune thrombocytopenic purpura: This may be explained by two mechanisms: first, platelet 5-HT storage capacity declines with age (54), and melatonin secretion is also reduced in the elderly (55), exacerbating sleep disruption when platelet counts fall; second, inflammaging places older adults in a chronic proinflammatory state, while ITP patients also exhibit elevated IL-6 (56), and inflammatory signals have been closely linked to sleep disturbances (57).