High-power microscopy showed spindled cells in a delicate vascular network with focal myxoid change (Figure 2B). Next-generation sequencing detected an in-frame AHRR: NCOA2 gene fusion between exon 9 of AHRR and exon 16 of NCOA2, which is a recurrent finding in angiofibroma of soft tissue. This evidence concerns the gene NCOA2 and Angiofibroma.