For example, PSME2 overexpression can suppress autophagic flux via the mTOR/Beclin-1 pathway to promote renal cell carcinoma metastasis [8]; it has been implicated in transcriptional activation in Burkitt’s lymphoma [8]; and it serves as a diagnostic marker in cutaneous melanoma and a predictor of lymph node metastasis in breast carcinoma [9,10]. The gene discussed is PSME2; the disease is renal cell carcinoma.