ALDH1A3 and cancer: Given that ALDH1A3 inhibition in ALDH1A3-positive cancer cell lines did not result in any obvious phenotypes in vitro despite showing effects in vivo, we next sought to perform detailed metabolomic and transcriptomic profiling to assess if either ALDH1A3 inhibition resulted in retinoid-independent effects or if MBE1.5 possessed off-target activity that was not detected by TPP/CETSA.