When plotted as individual heatmaps color-coded for humoral and cellular response levels across the Ttx, Tut, and C cohorts prior to and after the booster vaccination, and further informed by the tumor type (solid vs. hematological), we observed non-responders (i.e., no humoral and no CD4+ or CD8+ T cell response) in none of the C or Tut participants, but in a small subset of patients with Ttx. The gene discussed is CD4; the disease is neoplasm.