The final set of 20 targets (Figure 1E) included both genes with limited prior investigation as CAD GWAS genes (e.g., C1S, CRISPLD2, CTTN, and GEM), as well as genes with established roles in plaque SMCs or SMC-derived cells (e.g., LMOD1, MFGE8, TCF21, and PDGFD).21 Here, GEM is linked to coronary artery disorder.