SIRT1 and glioblastoma: Figure 7C show the PPI network consisting of the 167 gene nodes and 770 edges correlated with SCARB2 (R > 0.4, confidence more than 0.4). Furthermore, we utilized the CytoHubba application to construct particular PPI network containing SCARB2, IGF2R, SIRT1, FYN, NPC1, ABCG1 and AGFG1 nodes (Figure 7D). GSEA consistently demonstrated the significant enrichment of RUNX3/Notch signaling, BMP pathway and GBM signaling pathway in group with high SCARB2 expression levels (Figure 7E).