The treatment was well tolerated, but a few months later, while being treated with 20 mg/die of prednisone, the patient had another major relapse characterized by high fever, severe chest pain, large pericardial effusion, marked elevation of inflammatory markers (CRP 104 mg/L), and an episode of atrial fibrillation, cardioverted to sinus rhythm with IV flecainide. The gene discussed is CRP; the disease is pericardial effusion.