In this research, we found that the expression of PIBF and Galectin-1 in cervicitis and CIN1 patients was significantly lower than that in the high-grade cervical lesions group, indicating that PIBF and Galectin-1 may promote the invasion of lesion cells in cervical lesions, and PIBF and Galectin-1 were significantly increased in CIN3 patients, and the difference was statistically significant. The gene discussed is LGALS1; the disease is cervicitis.